Metabolomic Study on the Preventive Effect of Patrinia scabiosaefolia Fisch on Multipathogen Induced Pelvic Inflammatory Disease in Rats
Joint Authors
Zou, Wei
Wen, Xiaoke
Zheng, Yi
Luo, Jieying
Chen, Shuqiong
Wang, Yichao
Cheng, Zeneng
Xiang, Daxiong
Nie, Yichu
Xiao, Zuoqi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Patrinia scabiosaefolia Fisch (PSF), a well-known traditional Chinese medicine (TCM), has been used as a “heat-clearing and detoxifying” agent.
The present study was to illustrate the preventive effect of PSF on pelvic inflammatory disease (PID) in rats.
The PID model was constructed by multipathogen infection of the upper genital tract with reference to the method previously reported.
Urine metabolomic analysis was conducted with a GC-MS coupled with derivatization method.
In this study, PID rats showed obvious infiltration of inflammatory cells and elevated expression of cytokines (IL-1β and IL-6) in upper genital tract, compared with control rats.
Sixteen differentiating metabolites contributed to the alteration of metabolic profile in PID rats, including two amino acids, three fat acids, nine organic acids, and two types of sugars.
The rats, infected by multipathogen and administered with PSF, showed decreased infiltration of inflammatory cells and lowered expression of cytokines in upper genital tract, compared with PID rats.
Meanwhile, PSF intervened in the PID-associated alterations in TCA cycle, sugar metabolism, amino acid metabolism, and other uncertain metabolic pathways.
These results indicate that PSF has preventive effect on multipathogen induced PID and holistic interventional effect on disease-associated metabolomic change.
American Psychological Association (APA)
Zou, Wei& Wen, Xiaoke& Zheng, Yi& Xiao, Zuoqi& Luo, Jieying& Chen, Shuqiong…[et al.]. 2015. Metabolomic Study on the Preventive Effect of Patrinia scabiosaefolia Fisch on Multipathogen Induced Pelvic Inflammatory Disease in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061200
Modern Language Association (MLA)
Zou, Wei…[et al.]. Metabolomic Study on the Preventive Effect of Patrinia scabiosaefolia Fisch on Multipathogen Induced Pelvic Inflammatory Disease in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061200
American Medical Association (AMA)
Zou, Wei& Wen, Xiaoke& Zheng, Yi& Xiao, Zuoqi& Luo, Jieying& Chen, Shuqiong…[et al.]. Metabolomic Study on the Preventive Effect of Patrinia scabiosaefolia Fisch on Multipathogen Induced Pelvic Inflammatory Disease in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061200