Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model

Joint Authors

Song, Jingjing
Wang, Yingwu
Teng, Meiyu
Cai, Guangsheng
Xu, Hongkai
Guo, Hanxiao
Liu, Yang
Teng, Lesheng
Wang, Di

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-08-17

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Medicine

Abstract EN

Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities.

Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model.

Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test.

Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species.

Further data suggests that CM-induced fatigue recovery is mainly through activating 5′-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level.

Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect.

Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

American Psychological Association (APA)

Song, Jingjing& Wang, Yingwu& Teng, Meiyu& Cai, Guangsheng& Xu, Hongkai& Guo, Hanxiao…[et al.]. 2015. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061206

Modern Language Association (MLA)

Song, Jingjing…[et al.]. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1061206

American Medical Association (AMA)

Song, Jingjing& Wang, Yingwu& Teng, Meiyu& Cai, Guangsheng& Xu, Hongkai& Guo, Hanxiao…[et al.]. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061206

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1061206