Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model
Joint Authors
Song, Jingjing
Wang, Yingwu
Teng, Meiyu
Cai, Guangsheng
Xu, Hongkai
Guo, Hanxiao
Liu, Yang
Teng, Lesheng
Wang, Di
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities.
Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model.
Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test.
Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species.
Further data suggests that CM-induced fatigue recovery is mainly through activating 5′-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level.
Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect.
Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.
American Psychological Association (APA)
Song, Jingjing& Wang, Yingwu& Teng, Meiyu& Cai, Guangsheng& Xu, Hongkai& Guo, Hanxiao…[et al.]. 2015. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061206
Modern Language Association (MLA)
Song, Jingjing…[et al.]. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1061206
American Medical Association (AMA)
Song, Jingjing& Wang, Yingwu& Teng, Meiyu& Cai, Guangsheng& Xu, Hongkai& Guo, Hanxiao…[et al.]. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061206