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In Vitro Antimicrobial and Antiproliferative Activity of Amphipterygium adstringens
Joint Authors
Teixeira, I. P.
Rodriguez-Garcia, A.
Verde-Star, M. J.
De la Torre-Zavala, S.
Aviles-Arnaut, H.
Ruiz, A. L. T. G.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Amphipterygium adstringens is a plant widely used in Mexican traditional medicine for its known anti-inflammatory and antiulcer properties.
In this work, we evaluated the in vitro antimicrobial and antiproliferative activities of the methanolic extract of A.
adstringens against oral pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Candida albicans, and Candida dubliniensis, using microdilution (MIC) and agar diffusion methods (MBC), and the antiproliferative activity evaluating total growth inhibition (TGI) by staining the protein content with sulforhodamine B (SRB), using nine human cancer cell lines.
Crude extract (CE) of A.
adstringens showed some degree of activity against one or more of the strains with a MIC from 0.125 mg/mL to 63 mg/mL and MBC from 1.6 to 6.3 mg/mL and cytotoxic activity, particularly against NCI-ADR/RES, an ovarian cell line expressing multiple resistance drugs phenotype.
The CE is a complex mixture of possible multitarget metabolites that could be responsible for both antimicrobial and antiproliferative activities, and further investigation is required to elucidate the identity of active compounds.
Nevertheless the CE itself is useful in the development of new antimicrobial treatment based on natural products to prevent oral diseases and as alternative natural source for cancer treatment and prevention.
American Psychological Association (APA)
Rodriguez-Garcia, A.& Teixeira, I. P.& Verde-Star, M. J.& De la Torre-Zavala, S.& Aviles-Arnaut, H.& Ruiz, A. L. T. G.. 2015. In Vitro Antimicrobial and Antiproliferative Activity of Amphipterygium adstringens. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061207
Modern Language Association (MLA)
Rodriguez-Garcia, A.…[et al.]. In Vitro Antimicrobial and Antiproliferative Activity of Amphipterygium adstringens. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061207
American Medical Association (AMA)
Rodriguez-Garcia, A.& Teixeira, I. P.& Verde-Star, M. J.& De la Torre-Zavala, S.& Aviles-Arnaut, H.& Ruiz, A. L. T. G.. In Vitro Antimicrobial and Antiproliferative Activity of Amphipterygium adstringens. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061207