ERK12 and HIF1α Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis
Joint Authors
Saavedra, Nicolás
Salazar, Luis A.
Cuevas, Alejandro
Rudnicki, Martina
Abdalla, Dulcineia S. P.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Propolis has been shown to modulate the angiogenesis in both in vitro and in vivo models.
Thus, we aimed to evaluate the antiangiogenic properties of an ethanolic extract of Chilean propolis (EEP) and Pinocembrin (Pn).
Migration, formation of capillary-like structures of endothelial cells, and sprouting from rat aortic rings were used to assess the antiangiogenic properties of EEP or Pn.
In addition, microRNAs and VEGFA mRNA expression were studied by qPCR.
ERK1/2 phosphorylation and HIF1α stabilization were assessed by western blot.
EEP or Pn attenuated the migration, the capillary-like tube formation, and the sprouting in the in vitro assays.
In addition, the activation of HIF1α and ERK1/2 and the VEGFA mRNA expression was significantly inhibited in a dose-dependent manner.
In summary, these results suggest that HIF1α and ERK1/2 phosphorylation could be involved in the antiangiogenic effect of Chilean propolis, but more studies are needed to corroborate these findings.
American Psychological Association (APA)
Cuevas, Alejandro& Saavedra, Nicolás& Rudnicki, Martina& Abdalla, Dulcineia S. P.& Salazar, Luis A.. 2015. ERK12 and HIF1α Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061221
Modern Language Association (MLA)
Cuevas, Alejandro…[et al.]. ERK12 and HIF1α Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061221
American Medical Association (AMA)
Cuevas, Alejandro& Saavedra, Nicolás& Rudnicki, Martina& Abdalla, Dulcineia S. P.& Salazar, Luis A.. ERK12 and HIF1α Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061221