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Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice
Joint Authors
Shim, Insop
Park, Hyun-Jung
Shim, Hyun Soo
Kim, Jeom Yong
Kim, Joo Young
Park, Sun Kyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cancer related fatigue (CRF) is one of the most common side effects of cancer and its treatments.
A large proportion of cancer patients experience cancer-related physical and central fatigue so new strategies are needed for treatment and improved survival of these patients.
BST204 was prepared by incubating crude ginseng extract with ginsenoside-β-glucosidase.
The purpose of the present study was to examine the effects of BST204, mixture of ginsenosides on 5-fluorouracil (5-FU)-induced CRF, the glycogen synthesis, and biochemical parameters in mice.
The mice were randomly divided into the following groups: the naïve normal (normal), the HT-29 cell inoculated (xenograft), xenograft and 5-FU treated (control), xenograft + 5-FU + BST204-treated (100 and 200 mg/kg) (BST204), and xenograft + 5-FU + modafinil (13 mg/kg) treated group (modafinil).
Running wheel activity and forced swimming test were used for evaluation of CRF.
Muscle glycogen, serum inflammatory cytokines, aspartic aminotransferase (AST), alanine aminotransferase (ALT), creatinine (CRE), white blood cell (WBC), neutrophil (NEUT), red blood cell (RBC), and hemoglobin (HGB) were measured.
Treatment with BST204 significantly increased the running wheel activity and forced swimming time compared to the control group.
Consistent with the behavioral data, BST204 markedly increased muscle glycogen activity and concentrations of WBC, NEUT, RBC, and HGB.
Also, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), AST, ALT, and CRE levels in the serum were significantly reduced in the BST204-treated group compared to the control group.
This result suggests that BST204 may improve chemotherapy-related fatigue and adverse toxic side effects.
American Psychological Association (APA)
Park, Hyun-Jung& Shim, Hyun Soo& Kim, Jeom Yong& Kim, Joo Young& Park, Sun Kyu& Shim, Insop. 2015. Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061231
Modern Language Association (MLA)
Park, Hyun-Jung…[et al.]. Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061231
American Medical Association (AMA)
Park, Hyun-Jung& Shim, Hyun Soo& Kim, Jeom Yong& Kim, Joo Young& Park, Sun Kyu& Shim, Insop. Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061231