Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats
Joint Authors
Mohamad Zaid, Siti Sarah
Othman, Shatrah
Kassim, Normadiah M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that can disrupt the normal functions of the reproductive system.
The objective of the study is to investigate the potential protective effects of Tualang honey against BPA-induced uterine toxicity in pubertal rats.
The rats were administered with BPA by oral gavage over a period of six weeks.
Uterine toxicity in BPA-exposed rats was determined by the degree of the morphological abnormalities, increased lipid peroxidation, and dysregulated expression and distribution of ERα, ERβ, and C3 as compared to the control rats.
Concurrent treatment of rats with BPA and Tualang honey significantly improved the uterine morphological abnormalities, reduced lipid peroxidation, and normalized ERα, ERβ, and C3 expressions and distribution.
There were no abnormal changes observed in rats treated with Tualang honey alone, comparable with the control rats.
In conclusion, Tualang honey has potential roles in protecting the uterus from BPA-induced toxicity, possibly accounted for by its phytochemical properties.
American Psychological Association (APA)
Mohamad Zaid, Siti Sarah& Kassim, Normadiah M.& Othman, Shatrah. 2015. Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1061233
Modern Language Association (MLA)
Mohamad Zaid, Siti Sarah…[et al.]. Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1061233
American Medical Association (AMA)
Mohamad Zaid, Siti Sarah& Kassim, Normadiah M.& Othman, Shatrah. Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1061233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061233