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Anti-Inflammatory Effect of Combination of Scutellariae Radix and Liriopis Tuber Water Extract
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Scutellariae Radix and Liriopis Tuber have been used to treat the inflammatory diseases in traditional Korean medicine and anti-inflammatory effect of each herb has been shown partially in several articles.
However, the combined extract of these medicinal herbs (SL) has not been reported for its anti-inflammatory effects.
In this study, we investigated the effects of SL on the creation of several proinflammatory mediators in RAW 264.7 cell mouse macrophages induced by Lipopolysaccharide (LPS).
SL inhibited significantly the increase of NO, the release of intracellular calcium, the increase of interleukin-6 (IL-6), macrophage inflammatory proteins (MIP-1α, MIP-1β, and MIP-2), and granulocyte colony-stimulating factor (G-CSF) in LPS-induced RAW 264.7 cell at the concentrations of 25, 50, and 100 μg/mL, and SL inhibited significantly the increase of macrophage colony-stimulating factor (M-CSF) at the concentrations of 25 and 50 μg/mL, and tumor necrosis factor (TNF) at the concentration of 25 μg/mL.
These results implicate that SL has anti-inflammatory effects by suppressing the production of various inflammatory mediators in macrophages.
But SL did not inhibit significantly the increase of granulocyte macrophage colony-stimulating factor (GM-CSF), leukemia inhibitory factor (LIF), and Regulated on Activation, Normal T cell Expressed and Secreted (RANTES); therefore, further study is demanded for the follow-up research to find out the possibility of SL as a preventive and therapeutic medicine for various inflammatory diseases.
American Psychological Association (APA)
So, Mi-Hye& Choi, You-Kyung. 2015. Anti-Inflammatory Effect of Combination of Scutellariae Radix and Liriopis Tuber Water Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061235
Modern Language Association (MLA)
So, Mi-Hye& Choi, You-Kyung. Anti-Inflammatory Effect of Combination of Scutellariae Radix and Liriopis Tuber Water Extract. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061235
American Medical Association (AMA)
So, Mi-Hye& Choi, You-Kyung. Anti-Inflammatory Effect of Combination of Scutellariae Radix and Liriopis Tuber Water Extract. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061235