Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats
Joint Authors
Jin, Zhixing
Wang, Li
Zhu, Zhiling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the effect of GuiXiong Xiaoyi Wan (GXXYW) on the development of endometriosis in a rat model.
Methods.
Sprague-Dawley rats with surgically induced endometriosis were randomly treated with low-dose GXXYW, high-dose GXXYW, or vehicle (negative control) for 28 days.
Immunohistochemistry was used to assess cell proliferation in the lesions.
The terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP biotin nick end labelling (TUNEL) method was performed to analyse the apoptosis induced by GuiXiong Xiaoyi Wan.
The percentages of CD3+ lymphocytes, CD4+ lymphocytes, and CD8+ lymphocytes in the spleens of the rats were evaluated using flow cytometric analysis.
Results.
Treatment with GXXYW significantly decreased the lesion size, inhibited cell proliferation, and induced apoptosis in endometriotic tissue.
The spleens of GXXYW-treated rats also demonstrated a significant increase in the percentage of CD4+ lymphocytes and a significant decrease in the percentage of CD8+ lymphocytes.
Conclusions.
These results suggest that, in a rat model, GXXYW may be effective in the suppression of the growth of endometriosis, possibly through the inhibition of cell proliferation, the induction of apoptosis of endometriotic cells, and the regulation of the immune system.
American Psychological Association (APA)
Jin, Zhixing& Wang, Li& Zhu, Zhiling. 2015. Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061243
Modern Language Association (MLA)
Jin, Zhixing…[et al.]. Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061243
American Medical Association (AMA)
Jin, Zhixing& Wang, Li& Zhu, Zhiling. Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061243