Vitex agnus-castus L. (Verbenaceae) Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats
Joint Authors
Salgueiro, Clairce Luzia
Ishii-Iwamoto, Emy Luiza
Garcia, Rosângela F.
Moreno, Franciele Neves
Campos-Shimada, Lilian Brites
Costa, Silvio Claudio da
Cecchini, Alessandra Lourenço
Vitoriano, Adriana de Souza
Natali, Maria Raquel Marçal
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Vitex agnus-castus (VAC) is a plant that has recently been used to treat the symptoms of menopause, by its actions on the central nervous system.
However, little is known about its actions on disturbances in lipid metabolism and nonalcoholic fat liver disease (NAFLD), frequently associated with menopause.
Ovariectomized (OVX) rats exhibit increased adiposity and NAFLD 13 weeks after ovary removal and were used as animal models of estrogen deficiency.
The rats were treated with crude extract (CE) and a butanolic fraction of VAC (ButF) and displayed the beneficial effects of a reduction in the adiposity index and a complete reversion of NAFLD.
NAFLD reversion was accompanied by a general improvement in the liver redox status.
The activities of some antioxidant enzymes were restored and the mitochondrial hydrogen peroxide production was significantly reduced in animals treated with CE and the ButF.
It can be concluded that the CE and ButF from Vitex agnus-castus were effective in preventing NAFLD and oxidative stress, which are frequent causes of abnormal liver functions in the postmenopausal period.
American Psychological Association (APA)
Moreno, Franciele Neves& Campos-Shimada, Lilian Brites& Costa, Silvio Claudio da& Garcia, Rosângela F.& Cecchini, Alessandra Lourenço& Natali, Maria Raquel Marçal…[et al.]. 2015. Vitex agnus-castus L. (Verbenaceae) Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061248
Modern Language Association (MLA)
Moreno, Franciele Neves…[et al.]. Vitex agnus-castus L. (Verbenaceae) Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1061248
American Medical Association (AMA)
Moreno, Franciele Neves& Campos-Shimada, Lilian Brites& Costa, Silvio Claudio da& Garcia, Rosângela F.& Cecchini, Alessandra Lourenço& Natali, Maria Raquel Marçal…[et al.]. Vitex agnus-castus L. (Verbenaceae) Improves the Liver Lipid Metabolism and Redox State of Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061248