Follicular fluid insulin like growth factor binding protein-1 and oocyte maturation

Abstract EN

Objectives: to evaluate the role of insulin- like growth factor binding protein-I (IGFBP1) in follicular fluid on oocyte maturation.

Patients and Methods: 20 women undergoing ICSI procedure at Kamal Shaeer IVF Center and the International Islamic Center for Population Studies and Research from May 2002 to March 2003 due to severe male factor were selected to be included in the study.

The inclusion criteria : age less than 35 years old , Body Mass Index (BMI) 25-28, complete infertility work up with no abnormality apart from severe male factor that was the main indication for ICSI program.

All patients were rendered to; Ovarian super-stimulation using long (mid-luteal) protocol (GnRH analogue, and hMG).

hCG 10000 mlU as a triggering dose, Oocytes pick-up then done in 36 hours.

The retrieved follicular fluid was subjected for measuring its contents of progesterone, E2 and IGFBP-I.

Results: The mean value of IGFBP-I in studied cases found 133.67 ± 90.02 ng /ml, with a statistically positive significant correlation with follicular E2 (P=0.001) and progesterone, (P=0.05) and with other parameters of follicular development such as number of oocytes retrieved (P=0.02) and Metaphase II oocytes maturity (P=0.05).

This indicates that IGFBP-I has an active role in the folliculogenesis and oocyte maturation.

This indicates that this factor is affected only by local hormones, and exerts its action locally.

Conclusion: Follicular fluid IGFBP-I could be considered as a good marker for oocyte maturation .