Amelioration of Auditory Response by DA9801 in Diabetic Mouse
Joint Authors
Lee, Yeong Ro
Hong, Bin Na
Her, You Ri
Castañeda, Rodrigo
Moon, Hyo Won
Kang, Tong Ho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetes mellitus (DM) is a metabolic disease that involves disorders such as diabetic retinopathy, diabetic neuropathy, and diabetic hearing loss.
Recently, neurotrophin has become a treatment target that has shown to be an attractive alternative in recovering auditory function altered by DM.
The aim of this study was to evaluate the effect of DA9801, a mixture of Dioscorea nipponica and Dioscorea japonica extracts, in the auditory function damage produced in a STZ-induced diabetic model and to provide evidence of the mechanisms involved in enhancing these protective effects.
We found a potential application of DA9801 on hearing impairment in the STZ-induced diabetic model, demonstrated by reducing the deterioration produced by DM in ABR threshold in response to clicks and normalizing wave I–IV latencies and Pa latencies in AMLR.
We also show evidence that these effects might be elicited by inducing NGF related through Nr3c1 and Akt.
Therefore, this result suggests that the neuroprotective effects of DA9801 on the auditory damage produced by DM may be affected by NGF increase resulting from Nr3c1 via Akt transformation.
American Psychological Association (APA)
Lee, Yeong Ro& Hong, Bin Na& Her, You Ri& Castañeda, Rodrigo& Moon, Hyo Won& Kang, Tong Ho. 2015. Amelioration of Auditory Response by DA9801 in Diabetic Mouse. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061258
Modern Language Association (MLA)
Lee, Yeong Ro…[et al.]. Amelioration of Auditory Response by DA9801 in Diabetic Mouse. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061258
American Medical Association (AMA)
Lee, Yeong Ro& Hong, Bin Na& Her, You Ri& Castañeda, Rodrigo& Moon, Hyo Won& Kang, Tong Ho. Amelioration of Auditory Response by DA9801 in Diabetic Mouse. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061258