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Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3KAkt Pathway in PC-12 Cells
Joint Authors
Peng, Weijun
Zhang, Dongdong
Wang, Zhe
Sheng, Chenxia
Hui, Shan
Gong, Wei
Chen, Shuai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Icariin is a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that exerts a variety of pharmacological activities and shows promise in the treatment and prevention of Alzheimer’s disease.
In this study, we investigated the neuroprotective effects of icariin against amyloid beta protein fragment 25–35 ( A β 25 – 35 ) induced neurotoxicity in cultured rat pheochromocytoma PC12 cells and explored potential underlying mechanisms.
Our results showed that icariin dose-dependently increased cell viability and decreased A β 25 – 35 -induced apoptosis, as assessed by MTT assay and Annexin V/propidium iodide staining, respectively.
Results of western blot analysis revealed that the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed icariin-induced Akt phosphorylation, suggesting that the protective effects of icariin are associated with activation of the PI3K/Akt signaling pathway.
LY294002 also blocked the icariin-induced downregulation of proapoptotic factors Bax and caspase-3 and upregulation of antiapoptotic factor Bcl-2 in A β 25 – 35 -treated PC12 cells.
These findings provide further evidence for the clinical efficacy of icariin in the treatment of Alzheimer’s disease.
American Psychological Association (APA)
Zhang, Dongdong& Wang, Zhe& Sheng, Chenxia& Peng, Weijun& Hui, Shan& Gong, Wei…[et al.]. 2015. Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3KAkt Pathway in PC-12 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061261
Modern Language Association (MLA)
Zhang, Dongdong…[et al.]. Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3KAkt Pathway in PC-12 Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061261
American Medical Association (AMA)
Zhang, Dongdong& Wang, Zhe& Sheng, Chenxia& Peng, Weijun& Hui, Shan& Gong, Wei…[et al.]. Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3KAkt Pathway in PC-12 Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061261