Dynamical Regulation Analysis Identifies Molecular Mechanisms of Fuzheng-Huayu Formula against Hepatitis B-Caused Liver Cirrhosis
Joint Authors
Zhang, Hui
Dong, Shu
Wei, Bin
Liu, Ping
Song, Ya-Nan
Peng, Jing-hua
Su, Shi-Bing
Chen, Qi-long
Zhou, Qian-mei
Lu, Yi-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fuzheng-Huayu (FZHY) tablet was formulated based on Chinese medicine theory in treating liver fibrosis.
A clinical trial has indicated that FZHY can against hepatitis B-caused liver cirrhosis (HBC), but the underlying mechanism of FZHY efficacy is unclear.
Here, we report that miRNA expression levels are remarkably changed when FZHY formula was used in HBC patient’s treatment as a paradigm of trials.
Then, we functionally characterize the significant impact of potential kernel miRNAs by miRNA-target network analysis.
Enrichment analysis show that the FZHY formula dramatically effecting the molecular regulated module in HBC.
Thus, we infer that FZHY plays a critical function in HBC treatment process and directly regulated many important pathways, including but not limited to cell cycle, p53 signaling pathway, and TGF-β signaling pathway, suggesting a new strategy for investigating the molecular mechanism of FZHY treatment.
American Psychological Association (APA)
Chen, Qi-long& Lu, Yi-Yu& Peng, Jing-hua& Dong, Shu& Wei, Bin& Song, Ya-Nan…[et al.]. 2015. Dynamical Regulation Analysis Identifies Molecular Mechanisms of Fuzheng-Huayu Formula against Hepatitis B-Caused Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061267
Modern Language Association (MLA)
Chen, Qi-long…[et al.]. Dynamical Regulation Analysis Identifies Molecular Mechanisms of Fuzheng-Huayu Formula against Hepatitis B-Caused Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061267
American Medical Association (AMA)
Chen, Qi-long& Lu, Yi-Yu& Peng, Jing-hua& Dong, Shu& Wei, Bin& Song, Ya-Nan…[et al.]. Dynamical Regulation Analysis Identifies Molecular Mechanisms of Fuzheng-Huayu Formula against Hepatitis B-Caused Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061267