Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model
Joint Authors
Parsa, Yekta
Chavoshi-Nejad, Mehdi
Jangholi, Ehsan
Nekouyian, Noushin
Hosseini, Sahar
Seifaee, Amin
Rafiee, Shima
Karimi, Hossein
Mohsenikia, Maryam
Ashkani-Esfahani, Soheil
Yadollah-Damavandi, Soheila
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Delayed wound healing process is one of the most important concerns in diabetes.
Healing of wounds has four phases, namely, hemostasis, inflammation, proliferation, and remodeling.
For a successful repair, all four factors must occur properly.
Hence, we aimed to evaluate the healing effects of Hypericum perforatum (HP) on full-thickness diabetic skin wounds by using stereological methods.
Forty-eight female diabetic rats were randomly divided into four groups (n=12): gel base treated group, HP 5% gel treated group, HP 10% gel treated group, and the control group which received no treatment.
A circular 1 cm2 full-thickness wound was created on the animal’s neck and wound area was measured every three days.
After sacrificing the animals, skin samples were fixed and prepared for stereological evaluations.
Based on the results, HP treated group showed faster wound closure rate in comparison with control and vehicle groups (P<0.05).
In addition, numerical density of fibroblasts, volume density of collagen bundles, and mean diameter and volume densities of the vessels in HP group were significantly higher than control and vehicle groups.
The results of this study showed that HP has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.
American Psychological Association (APA)
Yadollah-Damavandi, Soheila& Chavoshi-Nejad, Mehdi& Jangholi, Ehsan& Nekouyian, Noushin& Hosseini, Sahar& Seifaee, Amin…[et al.]. 2015. Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1061272
Modern Language Association (MLA)
Yadollah-Damavandi, Soheila…[et al.]. Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1061272
American Medical Association (AMA)
Yadollah-Damavandi, Soheila& Chavoshi-Nejad, Mehdi& Jangholi, Ehsan& Nekouyian, Noushin& Hosseini, Sahar& Seifaee, Amin…[et al.]. Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1061272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061272