Inhibitory Effect of a French Maritime Pine Bark Extract-Based Nutritional Supplement on TNF-α-Induced Inflammation and Oxidative Stress in Human Coronary Artery Endothelial Cells

Joint Authors

McGrath, Kristine C. Y.
Li, Xiao-Hong
McRobb, Lucinda S.
Heather, Alison K.

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-11-17

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Oxidative stress and inflammation, leading to endothelial dysfunction, contribute to the pathogenesis of atherosclerosis.

The popularity of natural product supplements has increased in recent years, especially those with purported anti-inflammatory and/or antioxidant effects.

The efficacy and mechanism of many of these products are not yet well understood.

In this study, we tested the antioxidant and anti-inflammatory effects of a supplement, HIPER Health Supplement (HIPER), on cytokine-induced inflammation and oxidative stress in human coronary artery endothelial cells (HCAECs).

HIPER is a mixture of French maritime pine bark extract (PBE), honey, aloe vera, and papaya extract.

Treatment for 24 hours with HIPER reduced TNF-α-induced reactive oxygen species (ROS) generation that was associated with decreased NADPH oxidase 4 and increased superoxide dismutase-1 expression.

HIPER inhibited TNF-α induced monocyte adhesion to HCAECs that was in keeping with decreased expression of vascular cell adhesion molecule-1 and intercellular cell adhesion molecule-1 and decreased nuclear factor-kappa B (NF-κB) activation.

Further investigation of mechanism showed HIPER reduced TNF-α induced IκBα and p38 and MEK1/2 MAP kinases phosphorylation.

Our findings show that HIPER has potent inhibitory effects on HCAECs inflammatory and oxidative stress responses that may protect against endothelial dysfunction that underlies early atherosclerotic lesion formation.

American Psychological Association (APA)

McGrath, Kristine C. Y.& Li, Xiao-Hong& McRobb, Lucinda S. & Heather, Alison K.. 2015. Inhibitory Effect of a French Maritime Pine Bark Extract-Based Nutritional Supplement on TNF-α-Induced Inflammation and Oxidative Stress in Human Coronary Artery Endothelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061285

Modern Language Association (MLA)

McGrath, Kristine C. Y.…[et al.]. Inhibitory Effect of a French Maritime Pine Bark Extract-Based Nutritional Supplement on TNF-α-Induced Inflammation and Oxidative Stress in Human Coronary Artery Endothelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061285

American Medical Association (AMA)

McGrath, Kristine C. Y.& Li, Xiao-Hong& McRobb, Lucinda S. & Heather, Alison K.. Inhibitory Effect of a French Maritime Pine Bark Extract-Based Nutritional Supplement on TNF-α-Induced Inflammation and Oxidative Stress in Human Coronary Artery Endothelial Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061285

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1061285