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Sibjotang Increases Atrial Natriuretic Peptide Secretion in Beating Rabbit Atria
Joint Authors
Kim, Hye Yoom
Kang, Dae Gill
Lee, Yun Jung
Oh, Hyun Cheol
Kwon, Oh Jeong
Tan, Rui
Lee, Ho Sub
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sibjotang (Shizaotang), traditional herbal medicine formula, which was first documented in the Shanghanlun, has long been prescribed for the treatment of impairment of the body fluid homeostasis.
The purpose of the present study was to identify the effects of Sibjotang on the secretion of a cardiac hormone, atrial natriuretic peptide (ANP), one of the main hormones involved in the regulation of the body fluid and blood pressure homeostasis.
Water extract of Sibjotang increased ANP secretion concomitantly with an increase in atrial dynamics in a concentration-dependent manner.
Sibjotang-induced increase in ANP secretion and positive inotropic effect were attenuated by GO6976 and LY333531, selective inhibitors of conventional protein kinase C, but not Rottlerin, an inhibitor of novel PKCδ.
Similarly to the effect of Sibjotang, extracts of components of Sibjotang, Euphorbia kansui, and Daphne genkwa, but not Euphorbia pekinensis and Ziziphus jujuba, increased ANP secretion and atrial dynamics.
Ingredients of Sibjotang, apigenin, rosmarinic acid, and salvianolic acid B decreased ANP secretion and atrial dynamics.
These findings suggest that Sibjotang increases ANP secretion and atrial dynamics via activation of conventional protein kinase C signaling.
This finding provides experimental evidence for the rationale in the use of Sibjotang in the treatment of impairment of the regulation of body fluid and blood pressure homeostasis.
American Psychological Association (APA)
Kwon, Oh Jeong& Oh, Hyun Cheol& Lee, Yun Jung& Kim, Hye Yoom& Tan, Rui& Kang, Dae Gill…[et al.]. 2015. Sibjotang Increases Atrial Natriuretic Peptide Secretion in Beating Rabbit Atria. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061294
Modern Language Association (MLA)
Kwon, Oh Jeong…[et al.]. Sibjotang Increases Atrial Natriuretic Peptide Secretion in Beating Rabbit Atria. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061294
American Medical Association (AMA)
Kwon, Oh Jeong& Oh, Hyun Cheol& Lee, Yun Jung& Kim, Hye Yoom& Tan, Rui& Kang, Dae Gill…[et al.]. Sibjotang Increases Atrial Natriuretic Peptide Secretion in Beating Rabbit Atria. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061294