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Comparison of the Spasmolytic Effects of Jakyak-Gamcho Decoctions Derived via Different Extractants
Joint Authors
Kwak, Dongwook
Lee, Changwoo
Kong, Inseong
Lee, JaeChul
Choi, Donghee
Na, Changsu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To investigate whether differences in the amounts of effective index components in Jakyak-Gamcho decoctions derived via extraction with either water or ethanol were associated with differential spasmolytic effectiveness.
Methods.
The amounts of effective index components (paeoniflorin, benzoic acid, glycyrrhizin, and isoliquiritin) contained in water-extracted Jakyak-Gamcho decoction and 70% ethanol-extracted Jakyak-Gamcho decoction were compared by high-performance liquid chromatography.
Muscle cramp reduction rates were compared between the two decoctions by comparing the degrees of muscle contraction, measured as the tension developed during electrical stimulation, before and 1 and 2 h after injection in rats.
Results.
The relative amounts of effective index components were, on average, about 43% higher in the 70% ethanol-extracted decoction than in the water-extracted decoction.
Two hours after injection, 0.25 g/kg of 70% ethanol-extracted decoction produced a significantly greater spasmolytic effect than 0.25 g/kg of water-extracted Jakyak-Gamcho decoction or distilled water (both p < 0.05 ).
Conclusion.
Differences in the amounts of effective index components resulting from the use of different extractants were associated with differences in spasmolytic effectiveness.
Hence, it may be worthwhile to investigate alternative extraction methods in terms of extraction efficiency and in vivo effectiveness for various herbal medicines in the future.
American Psychological Association (APA)
Kwak, Dongwook& Lee, Changwoo& Kong, Inseong& Lee, JaeChul& Choi, Donghee& Na, Changsu. 2015. Comparison of the Spasmolytic Effects of Jakyak-Gamcho Decoctions Derived via Different Extractants. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061297
Modern Language Association (MLA)
Kwak, Dongwook…[et al.]. Comparison of the Spasmolytic Effects of Jakyak-Gamcho Decoctions Derived via Different Extractants. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061297
American Medical Association (AMA)
Kwak, Dongwook& Lee, Changwoo& Kong, Inseong& Lee, JaeChul& Choi, Donghee& Na, Changsu. Comparison of the Spasmolytic Effects of Jakyak-Gamcho Decoctions Derived via Different Extractants. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061297