Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway
Joint Authors
Huang, Xiaoying
Tang, Jiangfeng
Cai, Hui
Pan, Yi
He, Yicheng
Dai, Caijun
Chen, Ali
Yu, Xiaoming
Chen, Mayun
Zou, Lizhen
Wang, Liangxing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study aimed to investigate the therapeutic effect of monoammonium glycyrrhizinate (MAG) on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and possible mechanism.
Acute lung injury was induced in BALB/c mice by intratracheal instillation of LPS, and MAG was injected intraperitoneally 1 h prior to LPS administration.
After ALI, the histopathology of lungs, lung wet/dry weight ratio, protein concentration, and inflammatory cells in the bronchoalveolar lavage fluid (BALF) were determined.
The levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the BALF were measured by ELISA.
The activation of NF-κB p65 and IκB-α of lung homogenate was detected by Western blot.
Pretreatment with MAG attenuated lung histopathological damage induced by LPS and decreased lung wet/dry weight ratio and the concentrations of protein in BALF.
At the same time, MAG reduced the number of inflammatory cells in lung and inhibited the production of TNF-α and IL-1β in BALF.
Furthermore, we demonstrated that MAG suppressed activation of NF-κB signaling pathway induced by LPS in lung.
The results suggested that the therapeutic mechanism of MAG on ALI may be attributed to the inhibition of NF-κB signaling pathway.
Monoammonium glycyrrhizinate may be a potential therapeutic reagent for ALI.
American Psychological Association (APA)
Huang, Xiaoying& Tang, Jiangfeng& Cai, Hui& Pan, Yi& He, Yicheng& Dai, Caijun…[et al.]. 2015. Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061304
Modern Language Association (MLA)
Huang, Xiaoying…[et al.]. Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061304
American Medical Association (AMA)
Huang, Xiaoying& Tang, Jiangfeng& Cai, Hui& Pan, Yi& He, Yicheng& Dai, Caijun…[et al.]. Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061304