Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats
Joint Authors
Zhu, Shi-Feng
Zhao, Xian-Lin
Wan, Mei-Hua
Tang, Wen-Fu
Li, Juan
Guo, Hui
Zhang, Yumei
Xiang, Jin
Thrower, Edwin C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of acute pancreatitis (AP).
However, the potential pharmacological mechanism remains unclear.
This study explored the potential effective components and the pharmacokinetic characteristics of DCQD in target tissue in experimental acute pancreatitis in rats.
Methods.
Acute pancreatitis-like symptoms were first induced in rats and then they were given different doses of DCQD (6 g/kg, 12 g/kg, and 24 g/kg body weight) orally.
Tissue drug concentration, tissue pathological score, and inflammatory mediators in pancreas, intestine, and lung tissues of rats were examined after 24 hours, respectively.
Results.
Major components of DCQD could be found in target tissues and their concentrations increased in conjunction with the intake dose of DCQD.
The high-dose compounds showed maximal effect on altering levels of anti-inflammatory (interleukin-4 and interleukin-10) and proinflammatory markers (tumor necrosis factor α and interleukin-6) and ameliorating the pathological damage in target tissues P < 0.05 .
Conclusions.
DCQD could alleviate pancreatic, intestinal, and lung injury by altering levels of inflammatory cytokines in AP rats with tissue distribution of its components.
American Psychological Association (APA)
Zhao, Xian-Lin& Zhang, Yumei& Li, Juan& Wan, Mei-Hua& Zhu, Shi-Feng& Guo, Hui…[et al.]. 2015. Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061314
Modern Language Association (MLA)
Zhao, Xian-Lin…[et al.]. Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061314
American Medical Association (AMA)
Zhao, Xian-Lin& Zhang, Yumei& Li, Juan& Wan, Mei-Hua& Zhu, Shi-Feng& Guo, Hui…[et al.]. Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061314