Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-β1Smad3 Pathway
Joint Authors
Cui, Xiang-Ning
Zhao, Yi-Zhou
He, Yaoyao
Du, Bai
Fan, Huiting
Cao, Jian
Liu, Zi Wang
Zhao, Yonglie
Zhao, Xin
Zhao, Mingjing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Qili qiangxin (QL) capsule is a traditional Chinese medicine that is widely used for the treatment of patients with chronic heart failure (CHF) of all etiologies, although the exact mechanisms of action remain unclear.
CHF leads to pulmonary vascular remodelling and thickening of the alveolar-capillary barrier that may be important mechanisms in the poor clinical outcome in patients with end-stage heart failure.
We examined whether QL could improve lung injury in ischemic CHF by reducing lung remodeling.
Rats with myocardial infarct received QL (1.0 g/kg/day) for 4 weeks.
Echocardiographic and morphometric measurements were obtained followed by echocardiography, histological staining, and immunohistochemical analysis of lung sections.
CHF caused significant lung structural remodeling evidenced by collagen deposition and thickening of the alveolar septa after myocardial infarct that were greatly improved by QL.
Lung weight increased after infarct with no evidence of pulmonary edema and was normalized by QL.
QL also reduced lung transforming growth factor-β1 (TGF-β1), p-Smad3, tumor necrosis factor-α (TNF-α), and Toll-like receptor-4 (TLR4) expression.
Thus, QL reduces lung remodeling associated with CHF, mainly by suppressing the TGF-β1/Smad3 signaling pathway.
The mechanism may also involve inhibition of TLR4 intracellular signaling.
American Psychological Association (APA)
He, Yaoyao& Du, Bai& Fan, Huiting& Cao, Jian& Liu, Zi Wang& Zhao, Yonglie…[et al.]. 2015. Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-β1Smad3 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061330
Modern Language Association (MLA)
He, Yaoyao…[et al.]. Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-β1Smad3 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061330
American Medical Association (AMA)
He, Yaoyao& Du, Bai& Fan, Huiting& Cao, Jian& Liu, Zi Wang& Zhao, Yonglie…[et al.]. Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-β1Smad3 Pathway. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061330