Antifungal and Antibacterial Metabolites from a French Poplar Type Propolis

Abstract EN

During this study, the in vitro antifungal and antibacterial activities of different extracts (aqueous and organic) obtained from a French propolis batch were evaluated.

Antifungal activity was evaluated by broth microdilution on three pathogenic strains: Candida albicans, C.

glabrata, and Aspergillus fumigatus.

Antibacterial activity was assayed using agar dilution method on 36 Gram-negative and Gram-positive strains including Staphylococcus aureus.

Organic extracts showed a significant antifungal activity against C.

albicans and C.

glabrata (MIC80 between 16 and 31 µg/mL) but only a weak activity towards A.

fumigatus (MIC80 = 250 µg/mL).

DCM based extracts exhibited a selective Gram-positive antibacterial activity, especially against S.

aureus (SA) and several of its methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains (MIC100 30–97 µg/mL).

A new and active derivative of catechin was also identified whereas a synergistic antimicrobial effect was noticed during this study.