Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells
Joint Authors
Ko, Byoung-Seob
Lee, Hye Won
Park, In Sil
Go, Hiroe
Kil, Ki-Jung
Kim, Dong il
Park, Sunmin
Ryuk, Jin Ah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The present study was conducted to investigate the effect of Sagunja-tang on the lipid related disease in a rat model of menopausal hyperlipidemia and lipid accumulation in methyl-β-cyclodextrin-induced HepG2 cells.
In in vivo study using menopausal hyperlipidemia rats, Sagunja-tang reduced retroperitoneal and perirenal fat, serum lipids, atherogenic index, cardiac risk factor, media thickness, and nonalcoholic steatohepatitis score, when compared to menopausal hyperlipidemia control rats.
In HepG2 cells, Sagunja-tang significantly decreased the lipid accumulation, total cholesterol levels, and low-density/very-low-density lipoprotein levels.
Moreover, Sagunja-tang reversed the methyl-β-cyclodextrin-induced decrease in the protein levels of critical molecule involved in cholesterol synthesis, sterol regulatory element binding protein-2, and low-density lipoprotein receptor and inhibited protein levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase as well as activity.
Phosphorylation level of AMP-activated protein kinase was stimulated by Sagunja-tang.
These results suggest that Sagunja-tang has effect on inhibiting hepatic lipid accumulation through regulation of cholesterol synthesis and AMPK activity in vitro.
These observations support the idea that Sagunja-tang is bioavailable both in vivo and in vitro and could be developed as a preventive and therapeutic agent of hyperlipidemia in postmenopausal females.
American Psychological Association (APA)
Go, Hiroe& Ryuk, Jin Ah& Lee, Hye Won& Park, In Sil& Kil, Ki-Jung& Park, Sunmin…[et al.]. 2015. Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061354
Modern Language Association (MLA)
Go, Hiroe…[et al.]. Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061354
American Medical Association (AMA)
Go, Hiroe& Ryuk, Jin Ah& Lee, Hye Won& Park, In Sil& Kil, Ki-Jung& Park, Sunmin…[et al.]. Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061354