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Effectiveness and Safety of Manufactured Chinese Herbal Formula for Knee Osteoarthritis: Insights from a Systematic Review
Joint Authors
Wang, Shangquan
Wei, Xu
Zhu, Liguo
Yang, Shaofeng
Gong, Hao
Li, Linghui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-01
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Objective.
To assess the current clinical evidence of manufactured Chinese herbal formulae (MCHF) for knee osteoarthritis (KOA).
Methods.
Seven databases were searched from inception to May 2015.
Eligible randomized controlled trials investigating the effectiveness of MCHF for KOA were included.
Data extraction, methodological assessment, and meta-analyses were conducted according to the Cochrane standards.
Results.
A total of 17 kinds of MCHF were identified from the twenty-six included trials.
Meta-analyses showed that MCHF significantly relieved the global pain of knee joints, either used alone or combined with routine treatments.
Additionally, MCHF plus routine treatments significantly decreased the scores of WOMAC and Lequesne index.
However, there were no statistical differences between MCHF group and routine treatment group in walk-related pain and WOMAC scores.
No significant differences were found in Lysholm scores.
There were twenty-one trials that mentioned adverse events.
A pooled analysis showed that adverse events occurred more frequently in control group compared with MCHF group.
Conclusions.
Our results indicated that MCHF showed some potential benefits for KOA.
However, we still cannot draw firm conclusions due to the poor methodological quality of included trials.
More high-quality RCTs would help to confirm the evidence.
American Psychological Association (APA)
Zhu, Liguo& Yang, Shaofeng& Wang, Shangquan& Gong, Hao& Li, Linghui& Wei, Xu. 2015. Effectiveness and Safety of Manufactured Chinese Herbal Formula for Knee Osteoarthritis: Insights from a Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061363
Modern Language Association (MLA)
Zhu, Liguo…[et al.]. Effectiveness and Safety of Manufactured Chinese Herbal Formula for Knee Osteoarthritis: Insights from a Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1061363
American Medical Association (AMA)
Zhu, Liguo& Yang, Shaofeng& Wang, Shangquan& Gong, Hao& Li, Linghui& Wei, Xu. Effectiveness and Safety of Manufactured Chinese Herbal Formula for Knee Osteoarthritis: Insights from a Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1061363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061363