Acupuncture Attenuated Inflammation and Inhibited Th17 and Treg Activity in Experimental Asthma
Joint Authors
Wei, Ying
Wei, Kai
Dong, Ming
Zhang, Hongying
Lv, Yubao
Liu, Jiaqi
Liu, Feng
Xu, Fei
Dong, Jingcheng
Sun, Jing
Luo, Qing-li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acupuncture is an effective therapeutic method in asthma treatment in traditional Chinese medicine.
Here, we evaluated the effect of acupuncture on airway hyperresponsiveness (AHR) and the associated inflammatory changes as well as Th17 and Treg activity in ovalbumin- (OVA-) induced experimental asthma.
Our results revealed that acupuncture treatment significantly inhibited AHR, lung inflammation, and mucus secretion of experimental asthma mice.
Furthermore, a decrease in lymphocytes and eosinophils as well as neutrophils was observed in bronchoalveolar lavage fluid (BALF) of mice treated with acupuncture.
Acupuncture reduced the OVA specific IgE level as well as the Th17 cytokine levels including IL-17A, IL-17F, and IL-22 in the serum of the experimental asthma mice.
Acupuncture treatment group also had reduced CD4+IL-17A+ cell numbers and increased CD4+Foxp3+ cell numbers in BALF.
In addition, acupuncture could inhibit IL-17R, RORγt, p65, and the inhibitor of NF-κB kinase-α (IKKα) protein expression.
Our results indicated that acupuncture was effective in inhibiting AHR and inflammation in OVA-induced experimental asthma, which may be associated with the regulation of Th17 and Treg activity and NF-κB pathway.
American Psychological Association (APA)
Wei, Ying& Dong, Ming& Zhang, Hongying& Lv, Yubao& Liu, Jiaqi& Wei, Kai…[et al.]. 2015. Acupuncture Attenuated Inflammation and Inhibited Th17 and Treg Activity in Experimental Asthma. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061365
Modern Language Association (MLA)
Wei, Ying…[et al.]. Acupuncture Attenuated Inflammation and Inhibited Th17 and Treg Activity in Experimental Asthma. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061365
American Medical Association (AMA)
Wei, Ying& Dong, Ming& Zhang, Hongying& Lv, Yubao& Liu, Jiaqi& Wei, Kai…[et al.]. Acupuncture Attenuated Inflammation and Inhibited Th17 and Treg Activity in Experimental Asthma. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061365