Uncommon Trimethoxylated Flavonol Obtained from Rubus rosaefolius Leaves and Its Antiproliferative Activity
Joint Authors
Niero, Rivaldo
Ruiz, Ana Lúcia Tasca Gois
Petreanu, Marcel
Ferreira, Emili Kamila
Sagaz, Ana Paula M.
Vendramini-Costa, Débora B.
Campos, Adriana
Delle Monache, Franco
de Carvalho, João Ernesto
Cechinel Filho, Valdir
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated from R.
rosaefolius leaves.
The compounds were identified by conventional spectroscopic methods such as NMR-H1 and C13 and identified as 5,7-dihydroxy-6,8,4′-trimethoxyflavonol (1), 5-hydroxy-3,6,7,8,4′-pentamethoxyflavone (2), and tormentic acid (3).
Both hexane and dichloromethane fractions showed selectivity for multidrug-resistant ovary cancer cell line (NCI-ADR/RES) with total growth inhibition values of 11.1 and 12.6 μg/ml, respectively.
Compound 1 also showed selective activity against the same cell line (18.8 μg/ml); however, it was especially effective against glioma cells (2.8 μg/ml), suggesting that this compound may be involved with the in vitro antiproliferative action.
American Psychological Association (APA)
Petreanu, Marcel& Ferreira, Emili Kamila& Sagaz, Ana Paula M.& Vendramini-Costa, Débora B.& Ruiz, Ana Lúcia Tasca Gois& de Carvalho, João Ernesto…[et al.]. 2015. Uncommon Trimethoxylated Flavonol Obtained from Rubus rosaefolius Leaves and Its Antiproliferative Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061366
Modern Language Association (MLA)
Petreanu, Marcel…[et al.]. Uncommon Trimethoxylated Flavonol Obtained from Rubus rosaefolius Leaves and Its Antiproliferative Activity. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061366
American Medical Association (AMA)
Petreanu, Marcel& Ferreira, Emili Kamila& Sagaz, Ana Paula M.& Vendramini-Costa, Débora B.& Ruiz, Ana Lúcia Tasca Gois& de Carvalho, João Ernesto…[et al.]. Uncommon Trimethoxylated Flavonol Obtained from Rubus rosaefolius Leaves and Its Antiproliferative Activity. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061366