Toxicopathological Evaluation of Hydroethanol Extract of Dianthus basuticus in Wistar Rats
Joint Authors
Ashafa, Anofi Omotayo Tom
Kazeem, Mutiu Idowu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Dianthus basuticus is a commonly used medicinal plant in Basotho traditional medicine for the treatment of diabetes, but there is no report on its safety or toxicity.
Therefore, we evaluated the toxicity profile of the hydroethanol whole plant extract of Dianthus basuticus in Wistar rats.
Methods.
Acute toxicity test was performed with single oral administration of 100–3200 mg/kg body weight of D.
basuticus extract to rats and the animals were observed for 14 days for signs of toxicity.
The subacute toxicity experiment was conducted by oral administration of graded doses (200, 400, and 800 mg/kg) of D.
basuticus extract daily for 28 days.
Behavioural changes as well as haematological, biochemical, and histological parameters were then evaluated.
Results.
There was no observable sign of toxicity in the acute toxicity test.
There were significant decreases ( P < 0.05 ) in the feed and water intake as well as total cholesterol and triglycerides of the D.
basuticus extract-treated rats in subacute toxicity study.
There were no treatment related differences in the haematological, biochemical, and histopathological evaluations.
Conclusions.
Administration of hydroethanol extract of D.
basuticus may be safe at the dosages tested in this study but its continuous usage can cause anorexia.
American Psychological Association (APA)
Ashafa, Anofi Omotayo Tom& Kazeem, Mutiu Idowu. 2015. Toxicopathological Evaluation of Hydroethanol Extract of Dianthus basuticus in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061376
Modern Language Association (MLA)
Ashafa, Anofi Omotayo Tom& Kazeem, Mutiu Idowu. Toxicopathological Evaluation of Hydroethanol Extract of Dianthus basuticus in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061376
American Medical Association (AMA)
Ashafa, Anofi Omotayo Tom& Kazeem, Mutiu Idowu. Toxicopathological Evaluation of Hydroethanol Extract of Dianthus basuticus in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061376