A Metabolomics Approach to Stratify Patients Diagnosed with Diabetes Mellitus into Excess or Deficiency Syndromes
Joint Authors
Yang, Ming
Liu, Tao
Wu, Tao
Yang, Li-Li
Ji, Guang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The prevalence of type 2 diabetes continuously increases globally.
The traditional Chinese medicine (TCM) can stratify the diabetic patients based on their different TCM syndromes and, thus, allow a personalized treatment.
Metabolomics is able to provide metabolite biomarkers for disease subtypes.
In this study, we applied a metabolomics approach using an ultraperformance liquid chromatography (UPLC) coupled with quadruple-time-of-flight (QTOF) mass spectrometry system to characterize the metabolic alterations of different TCM syndromes including excess and deficiency in patients diagnosed with diabetes mellitus (DM).
We obtained a snapshot of the distinct metabolic changes of DM patients with different TCM syndromes.
DM patients with excess syndrome have higher serum 2-indolecarboxylic acid, hypotaurine, pipecolic acid, and progesterone in comparison to those patients with deficiency syndrome.
The excess patients have more oxidative stress as demonstrated by unique metabolite signatures than the deficiency subjects.
The results provide an improved understanding of the systemic alteration of metabolites in different syndromes of DM.
The identified serum metabolites may be of clinical relevance for subtyping of diabetic patients, leading to a personalized DM treatment.
American Psychological Association (APA)
Wu, Tao& Yang, Ming& Liu, Tao& Yang, Li-Li& Ji, Guang. 2015. A Metabolomics Approach to Stratify Patients Diagnosed with Diabetes Mellitus into Excess or Deficiency Syndromes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061381
Modern Language Association (MLA)
Wu, Tao…[et al.]. A Metabolomics Approach to Stratify Patients Diagnosed with Diabetes Mellitus into Excess or Deficiency Syndromes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061381
American Medical Association (AMA)
Wu, Tao& Yang, Ming& Liu, Tao& Yang, Li-Li& Ji, Guang. A Metabolomics Approach to Stratify Patients Diagnosed with Diabetes Mellitus into Excess or Deficiency Syndromes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061381