![](/images/graphics-bg.png)
ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model
Joint Authors
Lee, Seong-Jong
Han, Jong-Min
Lee, Jin-Seok
Im, Hwi-Jin
Jo, Hyun-Kyung
Yoo, Ho-Ryong
Kim, Yoon-Sik
Seol, In-Chan
Son, Chang Gue
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The medicinal plants Artemisia iwayomogi (A.
iwayomogi) and Curcuma longa (C.
longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM).
In this study we evaluated the effect of the water extract of a mixture of A.
iwayomogi and C.
longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model.
Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks.
Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg).
Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed.
ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers.
ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα).
The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model.
American Psychological Association (APA)
Lee, Seong-Jong& Han, Jong-Min& Lee, Jin-Seok& Son, Chang Gue& Im, Hwi-Jin& Jo, Hyun-Kyung…[et al.]. 2015. ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061385
Modern Language Association (MLA)
Lee, Seong-Jong…[et al.]. ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061385
American Medical Association (AMA)
Lee, Seong-Jong& Han, Jong-Min& Lee, Jin-Seok& Son, Chang Gue& Im, Hwi-Jin& Jo, Hyun-Kyung…[et al.]. ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061385