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Enhanced Protective Effect of the Combination of Uncaria and Semen Raphani on Vascular Endothelium in Spontaneously Hypertensive Rats
Joint Authors
Jiang, Yue-Hua
Yang, Chuan-Hua
Sun, Jing-Chang
Wang, Miao-Miao
Yang, Wen-Qing
Li, Yunlun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Endothelial dysfunction and low-grade inflammation are closely associated with hypertension and other cardiovascular diseases.
The combination of Uncaria (U) and Semen Raphani (R) is common in traditional Chinese medicine for the treatment of hypertension and heart diseases.
We aimed to investigate the therapeutic effect of the combination of Uncaria and Semen Raphani on spontaneously hypertensive rats (SHRs), and valsartan was used as a positive control.
In the present study, all extracts decreased systolic pressure, diastolic pressure, and mean arterial pressure.
U alone showed antihypertensive efficacy and effectively decreased CECs count, while R alone showed efficacy in relieving inflammatory level.
The combination of U and R showed enhanced effectiveness at lowering activated CECs and improving endothelial integrity of thoracic aorta and mesenteric artery and normalized the level of plasma biomarkers of endothelial damage.
The combination of U and R decreased the mRNA level of VCAM-1, Sel-L, TFPI, and Sel-P, while it elevated mRNA expression of FGF-1 and THBD of the thoracic aorta, which may be, at least in part, involved in the mechanism of protective effect on hypertensive endothelial injury.
American Psychological Association (APA)
Li, Yunlun& Jiang, Yue-Hua& Yang, Chuan-Hua& Sun, Jing-Chang& Wang, Miao-Miao& Yang, Wen-Qing. 2015. Enhanced Protective Effect of the Combination of Uncaria and Semen Raphani on Vascular Endothelium in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061389
Modern Language Association (MLA)
Li, Yunlun…[et al.]. Enhanced Protective Effect of the Combination of Uncaria and Semen Raphani on Vascular Endothelium in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061389
American Medical Association (AMA)
Li, Yunlun& Jiang, Yue-Hua& Yang, Chuan-Hua& Sun, Jing-Chang& Wang, Miao-Miao& Yang, Wen-Qing. Enhanced Protective Effect of the Combination of Uncaria and Semen Raphani on Vascular Endothelium in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061389