Effect of Aqueous Extract from Morinda officinalis F. C. How on Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats
Joint Authors
Song, Bin
Wang, Fengjuan
Wang, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study aimed to assess the protective effects of aqueous extract from Morinda officinalis F.
C.
How on microwave-induced reproductive impairment in male rats.
Microwave exposure injury was induced by exposure of 900 MHz microwaves at 218 μm/cm2 radiation densities, 24 hours/day for 10 days.
Male Sprague-Dawley rats were randomized to: normal control, microwave exposure model, or water layer or ethyl acetate layer of aqueous extract 40 g/kg treatment groups.
After 2 weeks of treatment, sexual performance, serum levels of gonadotrophin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) or testosterone, morphological analysis of testis and epididymis, and GnRH protein expression in the hypothalamus were measured.
Pretreatment with water layer of aqueous extract 40 g/kg significantly improved sexual performance, increased serum testosterone level, and decreased LH and GnRH level compared with microwave exposed model rats (all P<0.05).
Water layer of aqueous extract treatment significantly increased seminiferous cell or sperm number in testis and epididymis.
Protein expression of GnRH in the hypothalamus significantly decreased in the water layer of aqueous extract treated group (P<0.05).
Ethyl acetate layer of aqueous extract did not show obvious effects on the measured parameters.
These findings suggest that water layer of aqueous extract 40 g/kg ameliorates microwave-reduced reproductive impairment.
American Psychological Association (APA)
Song, Bin& Wang, Fengjuan& Wang, Wei. 2015. Effect of Aqueous Extract from Morinda officinalis F. C. How on Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061390
Modern Language Association (MLA)
Song, Bin…[et al.]. Effect of Aqueous Extract from Morinda officinalis F. C. How on Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061390
American Medical Association (AMA)
Song, Bin& Wang, Fengjuan& Wang, Wei. Effect of Aqueous Extract from Morinda officinalis F. C. How on Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061390