A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction
Joint Authors
Saegusa, Yayoi
Yamada, Chihiro
Hattori, Tomohisa
Nahata, Miwa
Takeda, Hiroshi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Because the clinical condition of gastrointestinal dysfunction, including functional dyspepsia, involves tangled combinations of pathologies, there are some cases of insufficient curative efficacy.
Thus, traditional herbal medicines (Kampo medicines) uniquely developed in Japan are thought to contribute to medical treatment for upper gastrointestinal symptoms.
Rikkunshito is a Kampo medicine often used to treat dyspeptic symptoms.
Over the past few years, several studies have investigated the efficacy of rikkunshito for dysmotility, for example, upper abdominal complaints, in animals and humans.
Rikkunshito ameliorated the decrease in gastric motility and anorexia in cisplatin-treated rats, stress-loaded mice, and selective serotonin reuptake inhibitor-treated rats by enhancing plasma ghrelin levels via serotonin2B/2C receptor antagonism.
In addition, rikkunshito ameliorated the decrease in food intake in aged mice and stress-loaded decreased gastric motility via enhanced ghrelin receptor signaling.
Several clinical studies revealed that rikkunshito was effective in ameliorating upper gastrointestinal symptoms, including dyspepsia, epigastric pain, and postprandial fullness.
In this review, we discuss these studies and propose additional evidence-based research that may promote the clinical use of Kampo medicines, particularly rikkunshito, for treating anorexia and gastrointestinal dysfunction.
American Psychological Association (APA)
Saegusa, Yayoi& Hattori, Tomohisa& Nahata, Miwa& Yamada, Chihiro& Takeda, Hiroshi. 2015. A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061399
Modern Language Association (MLA)
Saegusa, Yayoi…[et al.]. A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061399
American Medical Association (AMA)
Saegusa, Yayoi& Hattori, Tomohisa& Nahata, Miwa& Yamada, Chihiro& Takeda, Hiroshi. A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061399