Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses
Joint Authors
Jiang, Jian-Dong
Ma, Lin-Lin
Ge, Miao
Wang, Hui-Qiang
Yin, Jin-Qiu
Li, Yu-Huan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Influenza is still a serious threat to human health with significant morbidity and mortality.
The emergence of drug-resistant influenza viruses poses a great challenge to existing antiviral drugs.
Traditional Chinese medicines (TCMs) may be an alternative to overcome the challenge.
Here, 10 oral proprietary Chinese medicines were selected to evaluate their anti-influenza activities.
These drugs exhibit potent inhibitory effects against influenza A H1N1, influenza A H3N2, and influenza B virus.
Importantly, they demonstrate potent antiviral activities against drug-resistant strains.
In the study of mechanisms, we found that Xiaoqinglong mixture could increase antiviral interferon production by activating p38 MAPK, JNK/SAPK pathway, and relative nuclear transcription factors.
Lastly, our studies also indicate that some of these medicines show inhibitory activities against EV71 and CVB strains.
In conclusion, the 10 traditional Chinese medicines, as kind of compound combination medicines, show broad-spectrum antiviral activities, possibly also including inhibitory activities against strains resistant to available antiviral drugs.
American Psychological Association (APA)
Ma, Lin-Lin& Ge, Miao& Wang, Hui-Qiang& Yin, Jin-Qiu& Jiang, Jian-Dong& Li, Yu-Huan. 2015. Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061414
Modern Language Association (MLA)
Ma, Lin-Lin…[et al.]. Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061414
American Medical Association (AMA)
Ma, Lin-Lin& Ge, Miao& Wang, Hui-Qiang& Yin, Jin-Qiu& Jiang, Jian-Dong& Li, Yu-Huan. Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061414