Animal Study on Primary Dysmenorrhoea Treatment at Different Administration Times
Joint Authors
Gao, Li-Na
Fang, Ling
Pu, Bao-Chan
Liu, Rui
Li, Ai-zhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The new methods of different administration times for the treatment of primary dysmenorrhea are more widely used clinically; however, no obvious mechanism has been reported.
Therefore, an animal model which is closer to clinical evaluation is indispensable.
A novel animal experiment with different administration times, based on the mice oestrous cycle, for primary dysmenorrhoea treatment was explored in this study.
Mice were randomly divided into two parts (one-cycle and three-cycle part) and each part includes five groups (12 mice per group), namely, Jingqian Zhitong Fang (JQF) 6-day group, JQF last 3-day group, Yuanhu Zhitong tablet group, model control group, and normal control group.
According to the one-way ANOVAs, results (writhing reaction, and PG F 2 α , PGE2, NO, and calcium ions analysis by ELISA) of the JQF cycle group were in accordance with those of JQF last 3-day group.
Similarly, results of three-cycle continuous administration were consistent with those of one-cycle treatment.
In conclusion, the consistency of the experimental results illustrated that the novel animal model based on mice oestrous cycle with different administration times is more reasonable and feasible and can be used to explore in-depth mechanism of drugs for the treatment of primary dysmenorrhoea in future.
American Psychological Association (APA)
Pu, Bao-Chan& Fang, Ling& Gao, Li-Na& Liu, Rui& Li, Ai-zhu. 2015. Animal Study on Primary Dysmenorrhoea Treatment at Different Administration Times. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061417
Modern Language Association (MLA)
Pu, Bao-Chan…[et al.]. Animal Study on Primary Dysmenorrhoea Treatment at Different Administration Times. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061417
American Medical Association (AMA)
Pu, Bao-Chan& Fang, Ling& Gao, Li-Na& Liu, Rui& Li, Ai-zhu. Animal Study on Primary Dysmenorrhoea Treatment at Different Administration Times. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061417