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Arctigenin from Fructus Arctii (Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers
Joint Authors
Shon, Dong-Hwa
Jung, Sun Young
Back, Su Yeon
Do, Jeong-Ryong
Shin, Hee Soon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Fructus Arctii is used as a traditional herbal medicine to treat inflammatory diseases in oriental countries.
This study aimed to investigate effect of F.
Arctii extract on intestinal barrier function in human intestinal epithelial Caco-2 cells and to reveal the active component of F.
Arctii.
We measured transepithelial electrical resistance (TEER) value (as an index of barrier function) and ovalbumin (OVA) permeation (as an index of permeability) to observe the changes of intestinal barrier function.
The treatment of F.
Arctii increased TEER value and decreased OVA influx on Caco-2 cell monolayers.
Furthermore, we found that arctigenin as an active component of F.
Arctii increased TEER value and reduced permeability of OVA from apical to the basolateral side but not arctiin.
In the present study, we revealed that F.
Arctii could enhance intestinal barrier function, and its active component was an arctigenin on the functionality.
We expect that the arctigenin from F.
Arctii could contribute to prevention of inflammatory, allergic, and infectious diseases by reinforcing intestinal barrier function.
American Psychological Association (APA)
Shin, Hee Soon& Jung, Sun Young& Back, Su Yeon& Do, Jeong-Ryong& Shon, Dong-Hwa. 2015. Arctigenin from Fructus Arctii (Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061418
Modern Language Association (MLA)
Shin, Hee Soon…[et al.]. Arctigenin from Fructus Arctii (Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061418
American Medical Association (AMA)
Shin, Hee Soon& Jung, Sun Young& Back, Su Yeon& Do, Jeong-Ryong& Shon, Dong-Hwa. Arctigenin from Fructus Arctii (Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061418