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Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice
Joint Authors
Kim, Hyo Geun
Oh, Myung Sook
Jeong, Hyun Uk
Park, Gunhyuk
Kim, Hocheol
Kim, Hyo Geun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Obesity has become a global health problem, contributing to various diseases including diabetes, hypertension, cancer, and dementia.
Increasing evidence suggests that obesity can also cause neuronal damage, long-term memory loss, and cognitive impairment.
The leaves and the fruits of Morus alba L., containing active phytochemicals, have been shown to possess antiobesity and hypolipidemic properties.
Thus, in the present study, we assessed their effects on cognitive functioning in mice fed a high-fat diet by performing immunohistochemistry, using antibodies against c-Fos, synaptophysin, and postsynaptic density protein 95 and a behavioral test.
C57BL/6 mice fed a high-fat diet for 21 weeks exhibited increased body weight, but mice coadministered an optimized Mori Folium and Mori Fructus extract mixture (2 : 1; MFE) for the final 12 weeks exhibited significant body weight loss.
Additionally, obese mice exhibited not only reduced neural activity, but also decreased presynaptic and postsynaptic activities, while MFE-treated mice exhibited recovery of these activities.
Finally, cognitive deficits induced by the high-fat diet were recovered by cotreatment with MFE in the novel object recognition test.
Our findings suggest that the antiobesity effects of MFE resulted in recovery of the cognitive deficits induced by the high-fat diet by regulation of neural and synaptic activities.
American Psychological Association (APA)
Kim, Hyo Geun& Jeong, Hyun Uk& Park, Gunhyuk& Kim, Hocheol& Kim, Hyo Geun& Oh, Myung Sook. 2015. Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061427
Modern Language Association (MLA)
Kim, Hyo Geun…[et al.]. Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061427
American Medical Association (AMA)
Kim, Hyo Geun& Jeong, Hyun Uk& Park, Gunhyuk& Kim, Hocheol& Kim, Hyo Geun& Oh, Myung Sook. Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061427