Safety Evaluation of Chinese Medicine Injections with a Cell Imaging-Based Multiparametric Assay Revealed a Critical Involvement of Mitochondrial Function in Hepatotoxicity
Joint Authors
Zhu, Yan
Wang, Meng
Liu, Chen-Xiang
Dong, Ran-Ran
He, Shuang
Liu, Ting-Ting
Zhao, Tie-Chan
Wang, Zhi-Long
Shen, Xi-Ya
Zhang, Bo-Li
Gao, Xiu-Mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The safety of herbal medicine products has been a widespread concern due to their complex chemical nature and lack of proper evaluation methods.
We have adapted a sensitive and reproducible multiparametric cell-based high-content analysis assay to evaluate the hepatic-safety of four Chinese medicine injections and validated it with classical animal-based toxicity assays.
Our results suggested that the reported hepatotoxicity by one of the drugs, Fufangkushen injection, could be attributed at least in part to the interference of mitochondrial function in human HepG2 cells by some of its constituents.
This method should be useful for both preclinical screen in a drug discovery program and postclinical evaluation of herbal medicine preparations.
American Psychological Association (APA)
Wang, Meng& Liu, Chen-Xiang& Dong, Ran-Ran& He, Shuang& Liu, Ting-Ting& Zhao, Tie-Chan…[et al.]. 2015. Safety Evaluation of Chinese Medicine Injections with a Cell Imaging-Based Multiparametric Assay Revealed a Critical Involvement of Mitochondrial Function in Hepatotoxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061429
Modern Language Association (MLA)
Wang, Meng…[et al.]. Safety Evaluation of Chinese Medicine Injections with a Cell Imaging-Based Multiparametric Assay Revealed a Critical Involvement of Mitochondrial Function in Hepatotoxicity. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061429
American Medical Association (AMA)
Wang, Meng& Liu, Chen-Xiang& Dong, Ran-Ran& He, Shuang& Liu, Ting-Ting& Zhao, Tie-Chan…[et al.]. Safety Evaluation of Chinese Medicine Injections with a Cell Imaging-Based Multiparametric Assay Revealed a Critical Involvement of Mitochondrial Function in Hepatotoxicity. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061429