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Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats
Joint Authors
Mossa, Abdel-Tawab H.
Ibrahim, Faten M.
Mohafrash, Samia M. M.
Abou Baker, Doha H.
El Gengaihi, Souad
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The adverse effect of cypermethrin on the liver and kidney of weanling female rats and the protective effect of ethanolic extract of grape pomace were investigated in the present study.
Weanling female rats were given cypermethrin oral at a dose of 25 mg kg−1 body weight for 28 consecutive days.
An additional two Cyp-trated groups received extract at a dose of 100 and 200 mg kg−1 body weight, respectively, throughout the experimental duration.
Three groups more served as extract and control groups.
Administration of Cyp resulted in a significant increase in serum marker enzymes, for example, aminotransferases (AST and ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT), and increases the level of urea nitrogen and creatinine.
In contrast, Cyp caused significant decrease in levels of total protein and albumin and caused histopathological alterations in liver and kidneys of female rats.
Coadministration of the extract to Cyp-treated female rats restored most of these biochemical parameters to within normal levels especially at high dose of extract.
However, extract administration to Cyp-treated rats resulted in overall improvement in liver and kidney damage.
This study demonstrated the adverse biohistological effects of Cyp on the liver and kidney of weanling female rats.
The grape pomace extract administration prevented the toxic effect of Cyp on the above serum parameters.
The present study concludes that grape pomace extract has significant antioxidant and hepatorenal protective activity.
American Psychological Association (APA)
Mossa, Abdel-Tawab H.& Ibrahim, Faten M.& Mohafrash, Samia M. M.& Abou Baker, Doha H.& El Gengaihi, Souad. 2015. Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061433
Modern Language Association (MLA)
Mossa, Abdel-Tawab H.…[et al.]. Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061433
American Medical Association (AMA)
Mossa, Abdel-Tawab H.& Ibrahim, Faten M.& Mohafrash, Samia M. M.& Abou Baker, Doha H.& El Gengaihi, Souad. Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061433