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Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats
Joint Authors
Kim, Hye Yoom
Kang, Dae Gill
Lee, Yun Jung
Kho, Min Chul
Park, Ji Hun
Ahn, You Mee
Lee, Ho Sub
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Increased fructose ingestion has been linked to obesity, hyperglycemia, dyslipidemia, and hypertension associated with metabolic syndrome.
Blackcurrant (Ribes nigrum; BC) is a horticultural crop in Europe.
To induce metabolic syndrome, Sprague-Dawley rats were fed 60% high-fructose diet.
Treatment with BC (100 or 300 mg/kg/day for 8 weeks) significantly suppressed increased liver weight, epididymal fat weight, C-reactive protein (CRP), total bilirubin, leptin, and insulin in rats with induced metabolic syndrome.
BC markedly prevented increased adipocyte size and hepatic triglyceride accumulation in rats with induced metabolic syndrome.
BC suppressed oral glucose tolerance and protein expression of insulin receptor substrate-1 (IRS-1) and phosphorylated AMP-activated protein kinase (p-AMPK) in muscle.
BC significantly suppressed plasma total cholesterol, triglyceride, and LDL content.
BC suppressed endothelial dysfunction by inducing downregulation of endothelin-1 and adhesion molecules in the aorta.
Vascular relaxation of thoracic aortic rings by sodium nitroprusside and acetylcholine was improved by BC.
The present study provides evidence of the potential protective effect of BC against metabolic syndrome by demonstrating improvements in dyslipidemia, hypertension, insulin resistance, and obesity in vivo.
American Psychological Association (APA)
Park, Ji Hun& Kho, Min Chul& Kim, Hye Yoom& Ahn, You Mee& Lee, Yun Jung& Kang, Dae Gill…[et al.]. 2015. Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061440
Modern Language Association (MLA)
Park, Ji Hun…[et al.]. Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061440
American Medical Association (AMA)
Park, Ji Hun& Kho, Min Chul& Kim, Hye Yoom& Ahn, You Mee& Lee, Yun Jung& Kang, Dae Gill…[et al.]. Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061440