Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra
Joint Authors
Kou, Jian-Qun
Qin, Zheng-Hong
Xu, Yin-Li
Chen, Cao-Xin
Chen, Jie-Yu
Zhu, Qi
Yang, Lu
Wang, Shu-Zhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiotoxin (CTX) from Naja naja atra venom (NNAV) reportedly had analgesic effect in animal models but its role in inflammation and arthritis was unknown.
In this study, we investigated the analgesic, anti-inflammatory, and antiarthritic actions of orally administered CTX-IV isolated from NNAV on rodent models of inflammation and adjuvant arthritis.
CTX had significant anti-inflammatory effects in models of egg white induced nonspecific inflammation, filter paper induced rat granuloma formation, and capillary osmosis tests.
CTX significantly reduced the swelling of paw induced by egg white, the inflammatory exudation, and the formation of granulomas.
CTX reduced the swelling of paw, the AA clinical scores, and pathological alterations of joint.
CTX significantly decreased the number of the CD4 T cells and inhibited the expression of relevant proinflammatory cytokines IL-17 and IL-6.
CTX significantly inhibited the secretion of proinflammatory cytokine IL-6 and reduced the level of p-STAT3 in FLS.
These results suggest that CTX inhibits inflammation and inflammatory pain and adjuvant-induced arthritis.
CTX may be a novel therapeutic drug for treatment of arthritis.
American Psychological Association (APA)
Chen, Cao-Xin& Chen, Jie-Yu& Kou, Jian-Qun& Xu, Yin-Li& Wang, Shu-Zhi& Zhu, Qi…[et al.]. 2015. Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061442
Modern Language Association (MLA)
Chen, Cao-Xin…[et al.]. Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061442
American Medical Association (AMA)
Chen, Cao-Xin& Chen, Jie-Yu& Kou, Jian-Qun& Xu, Yin-Li& Wang, Shu-Zhi& Zhu, Qi…[et al.]. Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061442