Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate
Joint Authors
Botelho Lourenço, Emerson Luiz
Lima Prando, Thiago Bruno
Gasparotto Junior, Arquimedes
Jesus, Douglas Rossi
Dalsenter, Paulo Roberto
Gasparotto, Francielli
Barbosa, Lorena Neris
Martins, Leonardo Franco
Guedes, Karla Moraes Rocha
Dragunski, Douglas Cardoso
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products.
The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days.
The amount of food consumed and the body weight were weekly monitored.
Blood and urine samples were obtained for the assessment of serum parameters and renal function.
Histopathological analyses in target organs were also performed.
No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found.
In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control.
Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity in Wistar rats, indicating possible safety of this biofilm.
American Psychological Association (APA)
Jesus, Douglas Rossi& Barbosa, Lorena Neris& Lima Prando, Thiago Bruno& Martins, Leonardo Franco& Gasparotto, Francielli& Guedes, Karla Moraes Rocha…[et al.]. 2015. Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061444
Modern Language Association (MLA)
Jesus, Douglas Rossi…[et al.]. Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061444
American Medical Association (AMA)
Jesus, Douglas Rossi& Barbosa, Lorena Neris& Lima Prando, Thiago Bruno& Martins, Leonardo Franco& Gasparotto, Francielli& Guedes, Karla Moraes Rocha…[et al.]. Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061444