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Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the ThaiLanna Medicinal Plant Recipe Database “MANOSROI III”
Joint Authors
Manosroi, Aranya
Akazawa, Hiroyuki
Kitdamrongtham, Worapong
Akihisa, Toshihiro
Manosroi, Worapaka
Manosroi, Jiradej
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Thai/Lanna medicinal plant recipes have been used for the treatment of several diseases including liver cancer.
In this study, methanolic extracts (MEs) of 23 plants were tested for antiproliferative activity on human hepatoma cell line (Hep G2) by the sulforhodamine B (SRB) assay.
Nine MEs with potent antiproliferative activity (IC50 < 100 µg/mL) were obtained and further semipurified by liquid/liquid partition extraction.
The semipurified fractions were tested for the antiproliferative and antioxidative activities.
ME of Stemona collinsae and the semipurified extract and methanol-water fraction (MF) of Gloriosa superba gave the highest antiproliferative activity on HepG2 which were 4.79- and 50.07-fold cisplatin, respectively.
The semipurified fractions showed an increased antiproliferative activity.
MF of Caesalpinia sappan and HF of Senna alata showed the highest free radical scavenging and metal chelating activities, respectively.
The compound in n-hexane fraction (HF) of Ventilago denticulata which showed an increase in antiproliferative activity comparing to its ME was isolated and identified as emodin.
This study has demonstrated the potential of the ME from S.
collinsae, MF from G.
superba, and emodin isolated from V.
denticulata, for further development as an antiliver cancer agent.
American Psychological Association (APA)
Manosroi, Aranya& Akazawa, Hiroyuki& Kitdamrongtham, Worapong& Akihisa, Toshihiro& Manosroi, Worapaka& Manosroi, Jiradej. 2015. Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the ThaiLanna Medicinal Plant Recipe Database “MANOSROI III”. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061457
Modern Language Association (MLA)
Manosroi, Aranya…[et al.]. Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the ThaiLanna Medicinal Plant Recipe Database “MANOSROI III”. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061457
American Medical Association (AMA)
Manosroi, Aranya& Akazawa, Hiroyuki& Kitdamrongtham, Worapong& Akihisa, Toshihiro& Manosroi, Worapaka& Manosroi, Jiradej. Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the ThaiLanna Medicinal Plant Recipe Database “MANOSROI III”. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061457