Is Huachansu Beneficial in Treating Advanced Non-Small-Cell Lung Cancer? Evidence from a Meta-Analysis of Its Efficacy Combined with Chemotherapy
Joint Authors
Zhou, Bingduo
Wu, Fengying
Miao, Zhulei
Zhu, Shengliang
Yuan, Lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Huachansu, the sterilized water extract of Bufo bufo gargarizans toad skin, is used in China to alleviate the side-effects and enhance the therapeutic effect of chemotherapy in advanced non-small-cell lung cancer (NSCLC).
We conducted a meta-analysis to assess Huachansu’s efficacy.
Methods.
We extensively searched electronic databases (CENTRAL, EMBASE, MEDLINE, CBM, Cochrane Library, CNKI, CEBM, WFDP, CSCD, CSTD, and IPA) for randomized controlled trials containing Huachansu plus chemotherapy as the test group and chemotherapy as the control group.
Seventeen trials were selected based on the selection criteria.
The pooled relative ratio (RR) of indicators with 95% confidence interval (95% CI) was calculated for efficacy evaluation.
Results.
The meta-analysis demonstrated a statistically significant improvement in objective tumor response, one-year survival, Karnofsky performance status, pain relief, and alleviation of severe side-effects (nausea and vomiting, leukocytopenia) in the test group as compared to the control group, but no significant difference in thrombocytopenia.
Conclusions.
This study demonstrated the efficacy of Huachansu combined with chemotherapy in the treatment of advanced NSCLC.
However, limitations exist and high-quality trials are needed for further verification.
American Psychological Association (APA)
Zhou, Bingduo& Wu, Fengying& Yuan, Lin& Miao, Zhulei& Zhu, Shengliang. 2015. Is Huachansu Beneficial in Treating Advanced Non-Small-Cell Lung Cancer? Evidence from a Meta-Analysis of Its Efficacy Combined with Chemotherapy. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061468
Modern Language Association (MLA)
Zhou, Bingduo…[et al.]. Is Huachansu Beneficial in Treating Advanced Non-Small-Cell Lung Cancer? Evidence from a Meta-Analysis of Its Efficacy Combined with Chemotherapy. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061468
American Medical Association (AMA)
Zhou, Bingduo& Wu, Fengying& Yuan, Lin& Miao, Zhulei& Zhu, Shengliang. Is Huachansu Beneficial in Treating Advanced Non-Small-Cell Lung Cancer? Evidence from a Meta-Analysis of Its Efficacy Combined with Chemotherapy. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061468