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TCM Formula Xiaoyaosan Decoction Improves Depressive-Like Behaviors in Rats with Type 2 Diabetes
Joint Authors
Jin, Zhong-Ye
Li, Na
Liu, Qun
Li, Xiao-Juan
Bai, Xiao-Hui
Zhao, Hong-Bo
Jing, Yu-Xia
Yan, Zhi-Yi
Liu, Yue-Yun
Chen, Jia-Xu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The mechanism of depression with type 2 diabetes remains elusive, requiring further study.
Objective.
To evaluate the effect of TCM formula Xiaoyaosan on depressive-like behaviors in rats with type 2 diabetes.
Methods.
Rats were divided into 5 groups and drugs were administered during the model period of 21 days.
The model of depressive-like behaviors in rats with type 2 diabetes was induced by a high fat diet, low doses of STZ injection, and chronic restraint stress for 21 days.
The body weight, fasting blood glucose, ITT, OGTT, 5-HT, DA, depression behaviors, and morphological changes of formation were measured and observed.
Results.
After modeling, marked changes were found in model rats; behavioral analyses of rats indicated that this modeling method negatively impacts locomotor function.
In the H&E staining, changes were found predominately in the CA1 and DG subregions of the hippocampus.
After 21 days of treatment by fluoxetine and Xiaoyaosan, rats’ body weights, behaviors and fasting blood glucose, and hippocampal formation were modified.
Conclusions.
A new model of depressive-like behaviors in rats with type 2 diabetes was successfully created.
Xiaoyaosan and fluoxetine in this study independently contribute to exacerbate the disease progression.
American Psychological Association (APA)
Li, Na& Liu, Qun& Li, Xiao-Juan& Bai, Xiao-Hui& Liu, Yue-Yun& Zhao, Hong-Bo…[et al.]. 2015. TCM Formula Xiaoyaosan Decoction Improves Depressive-Like Behaviors in Rats with Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061481
Modern Language Association (MLA)
Li, Na…[et al.]. TCM Formula Xiaoyaosan Decoction Improves Depressive-Like Behaviors in Rats with Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061481
American Medical Association (AMA)
Li, Na& Liu, Qun& Li, Xiao-Juan& Bai, Xiao-Hui& Liu, Yue-Yun& Zhao, Hong-Bo…[et al.]. TCM Formula Xiaoyaosan Decoction Improves Depressive-Like Behaviors in Rats with Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061481