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Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice
Joint Authors
Hao, Lijun
Xie, Yuxi
Wu, Guikai
Cheng, Aibin
Liu, Xiaogang
Zheng, Rongjuan
Huo, Hong
Zhang, Junwei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice.
Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses.
HEM (200 mg/kg BW) was gavage before ethanol administration.
Subsequent serum alanine aminotransferase (ALT) level, aspartate aminotransaminase (AST) level, Maleic dialdehyde (MDA) level, hepatic total antioxidant status (TAOS), and activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were determined by ELISA and immunohistochemistry, respectively.
HEM administration markedly (P<0.05) decreased serum ALT, AST, and MDA levels.
The hepatic histopathological observations showed that HEM had a relatively significant role in mice model, which had alcoholic liver damage.
In conclusion, we observed that HEM (200 mg/kg BW) supplementation could restrain the hepatic damage caused by acute alcohol exposure.
American Psychological Association (APA)
Hao, Lijun& Xie, Yuxi& Wu, Guikai& Cheng, Aibin& Liu, Xiaogang& Zheng, Rongjuan…[et al.]. 2015. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061482
Modern Language Association (MLA)
Hao, Lijun…[et al.]. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1061482
American Medical Association (AMA)
Hao, Lijun& Xie, Yuxi& Wu, Guikai& Cheng, Aibin& Liu, Xiaogang& Zheng, Rongjuan…[et al.]. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061482