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Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells
Joint Authors
Huang, Chun
Chen, Wangsheng
Wang, Xiaowen
Zhao, Jinqiu
Li, Qian
Fu, Zhongxue
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Esophageal carcinoma is a major public health problem worldwide and one of the most aggressively malignant neoplasms.
Although considerable diagnostic and therapeutic progress has been made in recent years, the prognosis of EC patients still remains dismal due to high rates of recurrence/metastasis and invasion.
Previous studies have demonstrated that Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells.
Several lines of evidence have shown that Cripto-1 plays an important oncogenic role during tumorigenesis by promoting EMT.
The aim of our study was to evaluate the significance of Cripto-1 which plays a role in EMT and its metastasis in esophageal carcinoma.
Data of this study suggest that Cripto-1 overexpression is connected with the tumorigenesis and progression of esophageal carcinoma; shRNA might be feasible for the inhibition of the invasion and metastasis of esophageal carcinoma.
American Psychological Association (APA)
Huang, Chun& Chen, Wangsheng& Wang, Xiaowen& Zhao, Jinqiu& Li, Qian& Fu, Zhongxue. 2015. Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061484
Modern Language Association (MLA)
Huang, Chun…[et al.]. Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061484
American Medical Association (AMA)
Huang, Chun& Chen, Wangsheng& Wang, Xiaowen& Zhao, Jinqiu& Li, Qian& Fu, Zhongxue. Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061484