Effect of Tongxinluo on Nephrin Expression via Inhibition of Notch1Snail Pathway in Diabetic Rats
Joint Authors
Wang, Jin-Yang
Li, Jiaoyang
Zhou, Shengnan
Xu, LiPing
Cui, Fangqiang
Gao, Yanbin
Geng, Jianguo
Wang, Xinyao
Zou, Da-Wei
Zhang, Na
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Podocyte injury is an important mechanism of diabetic nephropathy (DN).
Accumulating evidence suggests that nephrin expression is decreased in podocyte in DN.
Moreover, it has been demonstrated that tongxinluo (TXL) can ameliorate renal structure disruption and dysfunction in DN.
However, the effect of TXL on podocyte injury in DN and its molecular mechanism is unclear.
In order to explore the effect of TXL on podocyte injury and its molecular mechanism in DN, our in vivo and in vitro studies were performed.
Our results showed that TXL increased nephrin expression in diabetic rats and in high glucose cultured podocyte.
Meanwhile, TXL decreased ICN1 (the intracellular domain of notch), HES1, and snail expression in podocyte in vivo and in vitro.
More importantly, we found that TXL protected podocyte from injury in DN.
The results demonstrated that TXL inhibited the activation of notch1/snail pathway and increased nephrin expression, which may be a mechanism of protecting effect on podocyte injury in DN.
American Psychological Association (APA)
Cui, Fangqiang& Zou, Da-Wei& Gao, Yanbin& Zhang, Na& Wang, Jin-Yang& Xu, LiPing…[et al.]. 2015. Effect of Tongxinluo on Nephrin Expression via Inhibition of Notch1Snail Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061487
Modern Language Association (MLA)
Cui, Fangqiang…[et al.]. Effect of Tongxinluo on Nephrin Expression via Inhibition of Notch1Snail Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061487
American Medical Association (AMA)
Cui, Fangqiang& Zou, Da-Wei& Gao, Yanbin& Zhang, Na& Wang, Jin-Yang& Xu, LiPing…[et al.]. Effect of Tongxinluo on Nephrin Expression via Inhibition of Notch1Snail Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061487