The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis
Joint Authors
Gao, Yu-Shan
Han, Lin
Ma, Yan
Qin, Jian-guo
Li, Li-na
Zhang, Xiao-yu
Guo, Yi
Song, Lin-mei
Luo, Yan-ni
Chi, Xiao-yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the effect of Jiangya Tongluo (JYTL) formula on renal function in rats with hypertensive nephrosclerosis.
A total of 21 spontaneously hypertensive rats (SHRs) were randomized into 3 groups: valsartan (10 mg/kg/d valsartan), JYTL (14.2 g/kg/d JYTL), and a model group (5 mL/kg/d distilled water); Wistar Kyoto rats comprised the control group (n = 7, 5 mL/kg/d distilled water).
Treatments were administered by gavage every day for 8 weeks.
Blood pressure, 24-h urine protein, pathological changes in the kidney, serum creatinine, and blood urea nitrogen (BUN) levels were estimated.
The contents of adrenomedullin (ADM) and angiotensin II (Ang II) in both the kidney and plasma were evaluated.
JYTL lowered BP, 24-h urine protein, serum creatinine, and BUN.
ADM content in kidneys increased and negatively correlated with BP, while Ang II decreased and negatively correlated with ADM, but there was no statistically significant difference of plasma ADM between the model and the treatment groups.
Possibly, activated intrarenal renin-angiotensin system (RAS) plays an important role in hypertensive nephrosclerosis and the protective function of ADM via local paracrine.
JYTL may upregulate endogenous ADM level in the kidneys and antagonize Ang II during vascular injury by dilating renal blood vessels.
American Psychological Association (APA)
Han, Lin& Ma, Yan& Qin, Jian-guo& Li, Li-na& Gao, Yu-Shan& Zhang, Xiao-yu…[et al.]. 2015. The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061492
Modern Language Association (MLA)
Han, Lin…[et al.]. The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061492
American Medical Association (AMA)
Han, Lin& Ma, Yan& Qin, Jian-guo& Li, Li-na& Gao, Yu-Shan& Zhang, Xiao-yu…[et al.]. The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061492