Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats
Joint Authors
Kou, Jian-Qun
Qin, Zheng-Hong
Xu, Yin-Li
Zhu, Qi
Wang, Shu-Zhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chronic kidney disease (CKD) becomes a global health problem with high morbidity and mortality.
Adriamycin- (ADR-) induced rodent chronic nephropathy is a classic experimental model of human minimal lesion nephrotic syndrome.
The present study investigated the effect of cobrotoxin (CTX) on ADR-induced nephropathy.
Rats were given 6 mg/kg ADR once through the tail vein to replicate ADR nephropathy model.
CTX was administered to rats daily by placing a fast dissolving CTX membrane strip under the tongue starting from 5 days prior to ADR administration until the end of experiment.
The results showed that CTX ameliorated the symptoms of ADR nephropathy syndrome with reduced body weight loss, proteinuria, hypoalbuminemia, dyslipidemia, serum electrolyte imbalance, oxidative stress, renal function abnormities, and kidney pathological lesions.
Anti-inflammatory cytokine IL-10 expression was elevated after CTX administration in ADR nephropathy model.
CTX inhibited the phosphorylation of IκB-α and NF-κB p65 nuclear translocation.
Meanwhile, CTX upregulated the protein level of podocyte-specific nephrin and downregulated the level of fibrosis-related TGF-β.
These findings suggest that CTX may be a potential drug for chronic kidney diseases.
American Psychological Association (APA)
Wang, Shu-Zhi& Xu, Yin-Li& Zhu, Qi& Kou, Jian-Qun& Qin, Zheng-Hong. 2015. Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061508
Modern Language Association (MLA)
Wang, Shu-Zhi…[et al.]. Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1061508
American Medical Association (AMA)
Wang, Shu-Zhi& Xu, Yin-Li& Zhu, Qi& Kou, Jian-Qun& Qin, Zheng-Hong. Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061508