Pien Tze Huang Inhibits Hypoxia-Induced Angiogenesis via HIF-1αVEGF-A Pathway in Colorectal Cancer
Joint Authors
Shen, Aling
Chen, Hongwei
Sferra, Thomas J.
Feng, Jianyu
Zhang, Yuchen
Chen, Youqin
Lin, Jiumao
Lin, Wei
Peng, Jun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hypoxia-induced angiogenesis plays an important role in the development and metastasis of solid tumors and is highly regulated by HIF-1α/VEGF-A pathway.
Therefore, inhibiting tumor angiogenesis via suppression of HIF-1α/VEGF-A signaling represents a promising strategy for anticancer treatment.
As a traditional Chinese medicine formula, Pien Tze Huang (PZH) has long been used as a folk remedy for cancer in China and Southeast Asia.
Previously, we reported that PZH inhibits colorectal cancer (CRC) growth both in vivo and in vitro.
To elucidate the antitumor mechanisms of PZH, in the present study we used human umbilical vein endothelial cells (HUVEC) and colorectal carcinoma HCT-8 cells to evaluate the effects of PZH on hypoxia-induced angiogenesis and investigated the underlying molecular mechanisms.
We found that PZH could inhibit hypoxia-induced migration and tube formation of HUVEC cells in a dose-dependent manner, although the low concentrations of PZH had no effect on HUVEC viability.
Moreover, PZH inhibited hypoxia-induced activation of HIF-1α signaling and the expression of VEGF-A and/or VEGFR2 in both HCT-8 and HUVEC cells.
Collectively, our findings suggest that PZH can inhibit hypoxia-induced tumor angiogenesis via suppression of HIF-1α/VEGF-A pathway.
American Psychological Association (APA)
Chen, Hongwei& Feng, Jianyu& Zhang, Yuchen& Shen, Aling& Chen, Youqin& Lin, Jiumao…[et al.]. 2015. Pien Tze Huang Inhibits Hypoxia-Induced Angiogenesis via HIF-1αVEGF-A Pathway in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061514
Modern Language Association (MLA)
Chen, Hongwei…[et al.]. Pien Tze Huang Inhibits Hypoxia-Induced Angiogenesis via HIF-1αVEGF-A Pathway in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061514
American Medical Association (AMA)
Chen, Hongwei& Feng, Jianyu& Zhang, Yuchen& Shen, Aling& Chen, Youqin& Lin, Jiumao…[et al.]. Pien Tze Huang Inhibits Hypoxia-Induced Angiogenesis via HIF-1αVEGF-A Pathway in Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061514