Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action
Joint Authors
Zhu, Shu
Wang, Haichao
Wu, Andrew H.
He, Li
Long, Wei
Zhou, Qiuping
Wang, Ping
Fan, Saijun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells.
In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses.
Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake.
In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases.
American Psychological Association (APA)
Wu, Andrew H.& He, Li& Long, Wei& Zhou, Qiuping& Zhu, Shu& Wang, Ping…[et al.]. 2015. Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061515
Modern Language Association (MLA)
Wu, Andrew H.…[et al.]. Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061515
American Medical Association (AMA)
Wu, Andrew H.& He, Li& Long, Wei& Zhou, Qiuping& Zhu, Shu& Wang, Ping…[et al.]. Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061515